Kev kho mob qog noj ntshav nyob ntawm cov ntaub ntawv kiv taub hau: Nov yog qhov nws tau txheeb hauv huab

Cov neeg mob qog noj ntshav thiab lawv cov kws kho mob muaj cov ntaub ntawv ntau ntxiv txog tus kab mob thiab nws txoj kev kho mob ntau dua li yav dhau los, thiab cov ntaub ntawv muaj txuas ntxiv mus rau qhov kiv taub hau. Txawm li cas los xij, tag nrho cov ntaub ntawv no tsis muaj txiaj ntsig yog tias tib neeg tsis tuaj yeem nkag siab txhua yam. 

Xav txog tus neeg mob qog noj ntshav, piv txwv li, leej twg yuav tau txais kev kuaj mob ntxov los ntawm kev tshuaj ntsuam xyuas uas tsim cov duab tomography (CT). Raws li lawv qhov kev kuaj mob thiab kev npaj kho mob tau nce mus, lawv cov neeg saib xyuas yuav nqa cov ntaub ntawv xws li MR thiab cov duab molecular, cov ntaub ntawv kab mob - uas tau nce zuj zus - thiab cov ntaub ntawv genomics. 

"Txhua yam no, ua ncaj ncees, yog qhov nyuaj heev rau pab pawg saib xyuas lawv tus kheej thaum lawv tab tom xav txog yuav ua li cas saib xyuas thiab kho cov neeg mob zoo," Louis Culot, GM ntawm genomics thiab oncology informationatics ntawm Philips, tau hais thaum lub sijhawm Amazon Web Services virtual kev tshwm sim rau kev lag luam kev noj qab haus huv. 

"Hauv oncology tam sim no, lossis hauv kev qhuab qhia kho mob, qhov no tseem ceeb vim tias kev kho mob tseem ceeb, kev cuam tshuam tseem ceeb," Culot tau hais. “Peb tsis yog xav tau cov ntaub ntawv rau cov ntaub ntawv. Dab tsi tuaj yeem saib xyuas cov tswv cuab hauv pab pawg raws li cov ntaub ntawv?

Txhawm rau kom tau txais txiaj ntsig zoo dua ntawm tag nrho cov ntaub ntawv no, cov neeg tsim kho tshiab tau tig mus rau cov cuab yeej xws li kev suav huab thiab kev kawm tshuab - nrog cov txiaj ntsig cawm txoj sia. Ntawm lub lim tiam no AWS qhov kev tshwm sim, Culot taug kev los ntawm Philips kev koom tes nrog MD Anderson Cancer Center ntawm University of Texas, uas yog lub hom phiaj los pab cov kws kho mob nqa tag nrho lawv cov ntaub ntawv los tsim cov phiaj xwm saib xyuas tus kheej rau cov neeg mob. 

Satnam Alag, SVP ntawm software engineering ntawm Grail, tau piav qhia tias nws lub tuam txhab siv huab thiab tshuab kev kawm li cas los tsim cov kab ke uas tuaj yeem tshuaj xyuas cov neeg mob rau ntau ntau hom mob qog noj ntshav ib zaug, tsis yog ib zaug. 

Nws yog ib qho nyuaj rau overstate qhov cuam tshuam ntawm kev kho mob qog noj ntshav thiab kev kho mob. Hauv 2020, muaj ntau dua 19 lab tus neeg mob qog noj ntshav thoob ntiaj teb, Alag tau sau tseg, thiab ze li 10 lab tus neeg tuag. Nws tau kwv yees tias ib ntawm peb tus txiv neej thiab ib ntawm plaub tus poj niam yuav muaj mob qog noj ntshav hauv lub neej.

“Kuv lossis ib tsev neeg puas yuav raug kuaj mob qog noj ntshav? Nws nyob qhov twg hauv kuv lub cev? Nws puas tuaj yeem kho tau? Los yog nws yuav tua kuv? Cov no yog cov lus nug uas peb feem ntau qhia, "Alag hais. 

Ua tsaug, thaum peb sau cov ntaub ntawv ntau ntxiv los kawm txog kev mob qog noj ntshav, cov kws tshawb fawb tseem tab tom tsim cov kev kho mob tshiab ntawm qhov clip ceev. Kev nce qib hauv molecular profiling tau pab cov kws tshawb fawb txheeb xyuas ntau pawg thiab cov kab mob qog noj ntshav, nrog rau cov kev kho mob sib txawv. Xyoo 2009, US FDA tau pom zoo yim yam tshuaj tiv thaiv kab mob, Culot tau sau tseg. Txog xyoo 2020, tus lej ntawd tau nce mus txog 57. Ntxiv rau qhov ntawd, tam sim no muaj txog 1,500 qhov kev sim tshuaj kho mob tam sim no qhib rau cov neeg mob qog noj ntshav. 

"Feem ntau, tam sim no muaj ntau pua txoj kev kho mob lossis kev kho mob ua ke, uas tuaj yeem siv los kho mob qog noj ntshav," Culot tau hais. “Yog li peb muaj ob qhov kev sib tw no, puas yog? Yuav ua li cas peb rub tag nrho cov ntaub ntawv no kom tau txais daim duab zoo dua ntawm tus neeg mob? Thiab tom qab ntawd nrog qhov kev xav ntawd, nws txhais li cas rau qhov kev kho mob zoo tshaj plaws?

Txhawm rau daws qhov teeb meem ntawd, cov kws kho mob ntawm MD Anderson tau tsim qhov Precision Oncology Decision Support (PODS) system - cov ntaub ntawv pov thawj uas pab cov kws kho mob soj ntsuam cov ntaub ntawv tseem ceeb xws li qhov tseeb hauv kev tsim tshuaj thiab kev sim tshuaj, nrog rau cov neeg mob cov lus teb rau kev kho mob. . Qhov no pab lawv tsim cov phiaj xwm kho tus kheej.

Xyoo 2020, MD Anderson koom tes nrog Philips thiab AWS los ua kom cov txheej txheem muaj rau cov kws kho mob thiab cov kws kho mob thoob plaws ntiaj teb. 

Lub kaw lus tsuas tuaj yeem muaj nyob hauv huab, Culot sau tseg, rau ntau qhov laj thawj. Muaj ntau cov ntaub ntawv khaws cia thiab cov ntaub ntawv loj heev uas yuav tsum tau tshwm sim. Nyob rau tib lub sijhawm, lub kaw lus yuav tsum muaj kev ruaj ntseg thiab ua raws li ntau tus neeg xauj tsev rau cov kws kho mob thoob plaws ntiaj teb. 

Tej zaum qhov tseem ceeb tshaj plaws, huab ua rau cov phiaj xwm kho tus kheej tiag tiag, Culot tau sau tseg, los ntawm kev tso cai rau cov kws kho mob sib koom tes thiab sib txuas lawv cov ntaub ntawv. 

"Tib neeg tham txog mob qog noj ntshav yog qhov teeb meem loj, tab sis nws kuj yog qhov kuv hu ua qhov teeb meem me me," Culot hais. Nws tau muab piv txwv ntawm tus neeg mob ntsws cancer uas paub tias nws muaj theem 4 mob ntsws cancer nrog kev hloov pauv tshwj xeeb. 

Nws tau hais tias "Koj ua rau subsetting thiab subsetting cov pej xeem yog li txawm tias cov tsev kho mob loj tshaj plaws qee zaum tsuas muaj ob peb tus neeg mob uas ua tau raws li cov txheej txheem uas peb tab tom sim kawm los ntawm," nws hais. "Yuav kom muaj peev xwm sib txuas cov ntaub ntawv - de- txheeb xyuas, nyob rau hauv txoj kev ua raws - yog li peb tuaj yeem kawm tau los ntawm nws, tau qhib los ntawm cov huab cua ecosystems."

Ib yam li ntawd, Satnam Alag ntawm Grail tau hais tias huab yog qhov tseem ceeb rau kev txhim kho Galleri, lub tuam txhab kev kuaj mob qog noj ntshav thaum ntxov. Qhov kev sim no yog tsim los kuaj pom ntau dua 50 hom mob qog noj ntshav raws li kev ntxiv rau kev kuaj mob qog noj ntshav ib leeg.

"Kev siv lub zog ntawm genomics thiab kev kawm tshuab xav tau kev suav ntau," Alag hais. "Cov ntaub ntawv loj heev yuav tsum tau sau thiab ntsuas." 

Los ntawm ib qho ntshav kos ib leeg, qhov kev sim Galleri siv DNA sequencing thiab tshuab kev kawm algorithms los txheeb xyuas cov DNA ntawm tus neeg mob cov hlab ntsha. Qhov kev kuaj xyuas tshwj xeeb rau cov cell-free nucleic acids (cfDNA) uas cov qog los hauv cov ntshav, uas tuaj yeem qhia koj tias hom mob qog noj ntshav hauv lub cev thiab qhov twg los. 

Alag tau hais tias "Tshwj tsis yog kev kuaj mob rau tus kheej nkaus xwb, peb yuav tsum tshuaj xyuas tib neeg rau mob qog noj ntshav," Alag tau hais. "Thiab qhov no yog tam sim no ua tau ua tsaug rau ob qhov kev hloov pauv thev naus laus zis loj uas tau tshwm sim hauv 20 xyoo dhau los. Ua ntej, lub zog ntawm genomics - tam sim no muaj peev xwm ua kom tiav DNA ... tsim terabytes ntawm cov ntaub ntawv raug nqi zoo hauv ob peb hnub. Qhov thib ob, yog qhov loj ntawm kev tsim kho tshiab hauv kev kawm tshuab. Peb tam sim no muaj kev paub-yuav ua li cas los tsim cov qauv kev kawm nyuaj, sib sib zog nqus nrog kaum tawm lab tus yam ntxwv. "